呋喃西林是一種硝基呋喃類抗菌藥物，曾被廣泛應(yīng)用于水產(chǎn)養(yǎng)殖過程中。呋喃西林在動物體內(nèi)的代謝物氨基脲（SEM）會與細(xì)胞膜蛋白緊密結(jié)合，形成結(jié)合態(tài)殘留物，穩(wěn)定而長期存在于動物體內(nèi)，具有致癌、致畸性。本文簡要介紹了呋喃西林藥物的藥理作用及其應(yīng)用，綜述了兩種應(yīng)用于SEM檢測的主要方法——高效液相色譜（HPLC）及其聯(lián)用技術(shù)和免疫分析法的研究進(jìn)展情況及其優(yōu)缺點(diǎn)，以及食品中的SEM來源，以期對呋喃西林藥物及其代謝物SEM有一個較為完整的了解，也為進(jìn)一步開展相關(guān)研究奠定理論基礎(chǔ)。
Research Progress on Nitrofurazone and Its Metabolite ofSemicarbazide in Animal-derived Food
Nitrofurazone，as anitrofuran antibiotic，had been widely used inaquaculture. However，the semicarbazide（SEM），a kind of metabolite generated bynitrofurazone within animal's body，could closelyincorporate with cell membrane protein to form bound residues which wouldexisted in animal's body for a long time with carcinogenicity andteratogenicity. In this paper，the pharmacologicaleffects and application of nitrofurazone were briefly introduced. Besides，the research progress，advantages anddisadvantages of the main methods for SEM detection，includinghigh performance liquid chromatography（HPLC）and its combined technology and immunoassay were summarized，the sources of SEM in food was also summarized，hoping to comprehensively recognize the nitrofurazone and itsmetabolite of semicarbazide，and to provide theoreticalfoundation for further research.
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